Clinical value of 99Tcm-MIBI SPECT/CT in the diagnosis of hyperparathyroidism

Abstract

Objective To evaluate the clinical value of 99Tcm- sestamibi (MIBI) single photon emission computed tomography/computerized tomography (99Tcm-MIBI SPECT/CT) imaging in hyperparathyroidism (HPT), and to investigate the diagnostic significance of different phase tomographic imaging and compare with 99Tcm-MIBI dual phase plane imaging. Methods All 54 patients underwent 99Tcm-MIBI dual-phase planar imaging, 99Tcm-MIBI SPECT/CT early tomographic fusion imaging, delayed tomographic fusion imaging. According to the clinical diagnostic criteria, the sensitivity of three imaging methods in the diagnosis of hyperparathyroidism and the lesions was analyzed. Results ⑴ The diagnostic sensitivity of the 99Tcm-MIBI dual-phase planar imaging was 75.9%(41/54). The diagnostic sensitivity of the 99Tcm-MIBI SPECT/CT early tomographic fusion imaging was 88.9%(48/54). The diagnostic sensitivity of 99Tcm-MIBI SPECT/CT delayed tomographic fusion imaging was 77.8%(42/54). ⑵ There were 74 lesions diagnosed by 99Tcm-MIBI dual phase planar imaging, 95 lesions diagnosed by 99Tcm-MIBI SPECT/CT early stage fusion imaging, and 78 lesions diagnosed by 99Tcm-MIBI SPECT/CT delayed fusion imaging. The detection rate of positive lesions in early stage tomography was the highest. ⑶ There were 4 cases of ectopic parathyroid lesions diagnosed by early CT fusion imaging, 3 cases by dual phase planar imaging and delayed CT fusion imaging. Conclusions 99Tcm-MIBI SPECT/CT is an effective method to locate the focus of HPT, especially early tomographic fusion imaging combined with serum parathyroid hormone (PTH) value can improve the diagnostic efficiency. Key words: Technetium Tc 99m sestamibi; Tomography, emission-computed, single-photon; Hyperparathyroidism