Abstract
Although a number of sensitive assays for the measurement of immune complexes in plasma or other body fluids have been described, a number of drawbacks limit the usefulness of these assays in clinical practice. These include lack of standardization, excessive interassay variation, and bias favoring the measurement of certain kinds of complexes and the exclusion of others. Such assays are useful for categorizing patients with suspected immune-mediated disease. Complement assays, by contrast, are standardized widely, reasonably reproducible, and quite sensitive to change during the course of a disease. Measurements of plasma complement levels repeatedly have been found to be reliable in predicting the course of a disease such as SLE but, as currently priced, are expensive and may not be cost-effective compared with other, more simple, assessments of disease activity.
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