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Abstract
Objective To investigate the clinical use of carotid ultrasonography and human plasma lipoprotein associated phospholipase A2 (Lp-PLA2) in the diagnosis and treatment of atherosclerotic cerebral infarction. Methods Eighty patients with atherosclerotic cerebral infarction, who were hospitalized in the Department of Neurology in our hospital between April 2015 and June 2016, were included in the study group, and 60 healthy subjects were included in the control group. The carotid ultrasonography was used to determine the formation of carotid intima plaque and carotid intima-media thickness (IMT) . The Lp-PLA2 was determined by luminescence immunoassay. The detection rate of carotid plaque, and the levels of IMT and Lp-PLA2 were compared between the two groups. According to the National Institutes of Health Stroke Scale (NIHSS) score, the study group was divided into the mild, moderate and severe sub-groups. The differences in the levels of IMT and Lp-PLA2 were compared between the sub-groups. The correlation between NIHSS score and the levels of IMT and Lp-PLA2 in the study group was analyzed. Results The detection rate of carotid plaque in the study group was higher than that in the control group (85% vs 63.33%, P<0.05) . The levels of IMT and Lp-PLA2 in the study group were higher than those in the control group [ (1.25±0.61) mm vs (0.67±0.31) mm, (187.33±60.31) ng/ml vs (166.18±56.16) ng/ml, P<0.05]. Among the sub-groups, the levels of IMT and Lp-PLA2 were the highest in the severe group, and the lowest in the mild group (P<0.05) . In addition, there was positive linear correlation between the NIHSS score and the levels of IMT and Lp-PLA2 in the study group (r=0.857, 0.672, P<0.05) . Conclusion The carotid ultrasonography and Lp-PLA2 show certain predictive value for atherosclerotic cerebral infarction, which can be used in the diagnosis and treatment of arteriosclerotic cerebral infarction. Key words: Ultrasonography, Doppler; Cerebral infarction; Arteriosclerosis; Human plasma lipoprotein associated phospholipase A2
Published Version
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