Clinical study of the Chinese medicine syndrome differentiation combined with HAART for the acquried immune deficiency syndrom dementia complex

Abstract

Objecve To observe the clinical effect and safety of the Chinese medicine syndrome differentiation combined with HAART for the ADC(acquried immune deficiency syndrom dementia complex). Methods A total of 80 patients with ADC were divided into the treatment group and control group based on random number table, 40 in each group. The patients in the control group were treated by highly active anti-retrovital therapy (HAART). The patients in the treatment group were treated with TCM treatment on the based of the control group. Both groups received the treatment for 3 months.These outcomes were measured: TCM syndrome integral, mini mental state examination(MMSE), daily behavior scale(ADL), change of clinical stage, and adverse reactions. Results The effect rate of treatment group was 82.5%, which was significant higher than 65% of the control group (χ2=8.115, P=0.024). After the treatment, the ADL integral of the treatment group (37.69 ± 5.31 vs. 33.67 ± 5.16; t=2.528, P=0.021) was significantly higher than that before the treatment; and the ADL integral of the control group(36.96 ± 5.52 vs. 34.54 ± 4.98; t=2.747, P=0.027) was significantly higher than that before the treatment.But there was no significant difference between the two groups after the treatment (t=2.003, P=0.139). After the treatment, the MMSE integral of the treatment group (24.76 ± 4.43 vs.19.97 ± 5.46; t=1.006, P=0.013) was significantly higher than that before the treatment; the MMSE integral of the control group(24.65 ± 4.36 vs. 20.11 ± 4.87; t=1.035, P=0.014) was significantly higher than that before the treatment. But there was no significant difference between the two groups after the treatment (t=0.953, P=0.347).There was no significant difference between the two groups in the clinical stage change (phase1 χ2=1.231, P=0.954; phase2 χ2=2.726, P=1.053). There was no adverse reaction in the two groups during the treatment. Conclusions The Traditional Chinese medcine combined with HAART was better than HAART alonein the treatment of ADC. Key words: HIV; Encephalopathy; Anti-HIV agents; Syndrome differentiation treatment; Clinical study