Clinical study of blood pressure variability in aged patients with H type hypertension

Abstract

Objective: To explore characteristics and influencing factors for blood pressure variability (BPV) in aged patients with H type hypertension. Methods: A total of 100 patients with essential hypertension, who were treated in our hospital from December 2012 to December 2013, were selected. According to serum level of homocysteine (Hcy), patients were divided into pure hypertension group (n = 42, Hcy < 15.4 μmol/L) and H type hypertension group. All patients received 24 h ambulatory blood pressure monitoring (24hABPM), and BPV indexes were recorded and compared between two groups. Correlation among BPV indexes and general data were analyzed, and multi-factor linear regression analysis was used to analyze influencing factors for BPV indexes. Results: Compared with pure hypertension group, there were significant increases in 24 h systolic blood pressure standard deviation [24hSSD, (12.80 ± 2.23) vs. (16.01 ± 3.11)], daytime SSD [dSSD, (11.58 ± 2.30) vs. (13.86 ± 2.26)] and nighttime SSD [nSSD, (9.41 ± 1.64) vs. (11.71 ± 2.34)] in H type hypertension group, p < .05 or p < .01. Pearson correlation analysis showed that Hcy, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were significantly positively correlated with 24hSSD, dSSD and nSSD (r = 0.201-0.508, p < .05 or p < .01). Multivariate linear regression analysis indicated that Hcy and TC were significantly positively correlated with 24hSSD, dSSD and nSSD (B = 0.194-0.546, p < .05 or p < .01). Conclusions: Systolic BPV in aged patients with H type hypertension was significantly higher than that of patients with pure hypertension, their serum Hcy level, TC elevating level were significantly positively correlated with systolic BPV and were major influencing factors for BPV in these patients.