Abstract
To elucidate the incidence of renal impairment in chronic hepatitis B (CHB) patients on adefovir dipivoxil (ADV). We retrospectively enrolled 127 CHB patients on ADV alone (38.6%) or in combination with lamivudine (61.4%) for over 12 months.Renal function was measured by estimated glomerular filtration rate (eGFR). And renal dysfunction was defined as mild ( 50%). During a treatment duration of 12 months, 2 patients (1.6%) developed mild renal impairment.At Month 36, there were 13 patients with renal damage (10.4%) and one case of hypertension with severe renal impairment plus bone pain.The characteristic of renal pathology was tubule injury.Modification of dosing interval or discontinuation of ADV may arrest a further decline of eGFR in CHB patients. Key words: Nucleotides; Nephrosis
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