Abstract
A decrease in CSF GABA in some psychiatric patients may be due to a negative relationship between CSF GABA and behavior related to agitation-activation. Our earlier observation of decreased CSF GABA in depression seems explainable on this basis. In psychotic patients prior to drug treatment we have some evidence for a reciprocal relationship between CSF or plasma HVA and CSF GABA. Early in neuroleptic treatment, we find CSF GABA significantly positively correlated with CSF HVA, and significantly negatively correlated with CSF or plasma prolactin. In preliminary work we have observed no relationship between CSF and plasma GABA and no effect of lithium treatment upon CSF or plasma GABA.
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