Abstract
The Objective: one of the essential regulators of carcinogenesis is MicroRNA-21 (miR-21). Yet little light has been shed on its effectiveness as a tumor marker compared to the conventional ones. Comparing the diagnostic value of established tumor markers in breast cancer (BC) such as carcinoembryonic antigen (CEA) and CA153 with circulating level of miR-21 is the aim of this study.Methods:The study included 89 BC patients. Amplification of the circulating levels of miR-21 and miR-16 done using real-time PCR qualitative detection, while electrochemiluminescence assays was used to detect circulating levels of CEA and CA153. The diagnostic sensitivity for BC was compared between the three.Results: The serum miR-21 levels were high significantly BC patients, as the latter had much higher levels (P<0.001). the CA153 and CEA sensitivities were 15.73% and 22.47% respectively, while miR-21 Sensitivity and specificity were 87.6% and 87.3%.Conclusion:in BC patients miR-21 exhibits far higher sensitivity for diagnoses than both CEA and CA153. Thus especially in the early stages of BC, miR-21 can become a potential indicator for diagnosis, albeit the clinical stage, PR and ER statuses were not correlated in this study.
Highlights
Cancer is one of the illnesses where the stage at which the disease is diagnosed plays a crucial role patients survival and quality of life. [1] A diagnostic indicator that can detect cancer in early stages is of great significance, especially for breast cancer (BC), as it is the most common cancer in woman.[2]
Comparing the diagnostic value of established tumor markers in breast cancer (BC) such as carcinoembryonic antigen (CEA) and cancer antigen 153 (CA153) with circulating level of miR-21 is the aim of this study
MicroRNAs are found to have close ties with development and formation of tumors and are involved in regulating many cellular processes. They are a class of noncoding RNAs composed of 19-25 nucleotides. [4] miR-21 is involved in oncogenic process and has been demonstrated to be an essential regulator, and due to its involvement in tumor formation, its level is raised in majority of human tumors
Summary
Cancer is one of the illnesses where the stage at which the disease is diagnosed plays a crucial role patients survival and quality of life. [1] A diagnostic indicator that can detect cancer in early stages is of great significance, especially for breast cancer (BC), as it is the most common cancer in woman.[2]. [1] A diagnostic indicator that can detect cancer in early stages is of great significance, especially for breast cancer (BC), as it is the most common cancer in woman.[2] One field of interested is that of tumor markers, due to their noninvasive, rapid and simple nature.[3]. Despite their low sensitivity and specificity, the carcinoembryogenic antigen (CEA) and cancer antigen 153 (CA153) are the commonest markers used. Considering the hormone receptor status and disease stage, miR-21 expression levels were compared, and its sensitivity for diagnosing BC was pitted against CEA and CA153
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
