Abstract
Alkylating agents have been used in the treatment of cancer for over 50 yr, with the nitrogen mustard alkylating agent mechlorethamine being one of the first antitumor drug used in clinical practice half a century ago. These compounds can bind to a variety of cellular structures such as membranes, RNA, proteins, and DNA. It is, however, the ability to form DNA interstrand crosslinks that appears to be the most important event with regard to their antitumor activity. In addition to the nitrogen mustard agents (melphalan, chlorambucil, cyclophosphamide, and ifosfamide), the platinum drugs (cisplatin, carboplatin, and oxaliplatin) have become some of the most widely used cytotoxic anticancer agents.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
