Abstract
Objective:To determine the clinical predictors of anticipatory emesis in patients treated with chemotherapy at a tertiary care cancer hospital.Methods:This was a cross-sectional study conducted on 200 patients undergoing first line chemotherapy with minimum of two cycles at inpatient department and chemotherapy bay of Shaukat Khanum Memorial Cancer Hospital and Research Centre Pakistan. Anticipatory nausea and vomiting develops before administration of chemotherapy. Clinical signs and symptoms in patients with or without anticipatory emesis were compared using chi square test statistics.Results:The mean age of the study participants was 36.68 years (SD±12.23). The mean numbers of chemotherapy cycles administered were 3.23 (SD±1.2). Chemotherapy related nausea and vomiting was experienced by 188 (94%) patients and anticipatory nausea vomiting was reported in 90 (45%) of patients. Greater proportions of patients with anticipatory emesis were females. Fourteen (15.5%) p-value=0.031 patients with anticipatory emesis had history of anxiety and depression. Fifty nine (65.5%) p-value =< 0.0001 patients with anticipatory emesis had severe nausea after last chemotherapy cycle. Forty six (51.11%) p=<0.0001 patients had motion sickness.Conclusion:Female gender, history of motion sickness, anxiety and depression, severe nausea and vomiting experienced in pervious cycle of chemotherapy were clinical predictors of anticipatory nausea and vomiting.
Highlights
Advent of new antiemetic regimens[1] and wide spread availability of guidelines[2,3,4,5] for chemotherapy induced nausea and vomiting is an integral component of oncology care
This is called anticipatory emesis which develops when the patient thinks about the treatment, nurse, doctor, the sight of hospital, chemotherapy bay or drugs
Predictors of anticipatory emesis in patients treated with chemotherapy
Summary
Advent of new antiemetic regimens[1] and wide spread availability of guidelines[2,3,4,5] for chemotherapy induced nausea and vomiting is an integral component of oncology care. The focus has been on nausea and vomiting occurring before administering the chemotherapy.[9] This is called anticipatory emesis which develops when the patient thinks about the treatment, nurse, doctor, the sight of hospital, chemotherapy bay or drugs. This can become a significant problem resulting in psychological barriers to treatment.[10]
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