Abstract
The Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) defines right heart failure (RHF) as signs and symptoms of persistent right ventricular (RV) dysfunction after left ventricular assist device (LVAD) implantation. RHF is further stratified by duration of inotrope requirement as mild (≤7 days), moderate (8–14 days), severe (>14 days), or severe acute (right ventricular assist device [RVAD] implantation). 1 Interagency Registry for Mechanically Assisted Circulatory Support. Appendix A - adverse event definitions. UAB School of Medicine. http://www.uab.edu/medicine/intermacs/appendices/app-a-5-0. Accessed February 13, 2017. Inotrope use for at least 14 days or RVAD implantation has been frequently used to define RHF after LVAD implantation in published studies. 2 Slaughter M.S. Rogers J.G. Milano C.A. et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009; 361: 2241-2251 Crossref PubMed Scopus (2428) Google Scholar , 3 Kormos R.L. Teuteberg J.J. Pagani F.D. et al. Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes. J Thorac Cardiovasc Surg. 2016; 139: 1316-1324 Abstract Full Text Full Text PDF Scopus (667) Google Scholar , 4 Drakos S.G. Janicki L. Horne B.D. et al. Risk factors predictive of right ventricular failure after left ventricular assist device implantation. Am J Cardiol. 2010; 105: 1030-1035 Abstract Full Text Full Text PDF PubMed Scopus (317) Google Scholar Severe RV failure has been associated with a 3-fold increase in risk of death at 6 months and is associated with significantly longer hospitalizations. 3 Kormos R.L. Teuteberg J.J. Pagani F.D. et al. Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes. J Thorac Cardiovasc Surg. 2016; 139: 1316-1324 Abstract Full Text Full Text PDF Scopus (667) Google Scholar , 4 Drakos S.G. Janicki L. Horne B.D. et al. Risk factors predictive of right ventricular failure after left ventricular assist device implantation. Am J Cardiol. 2010; 105: 1030-1035 Abstract Full Text Full Text PDF PubMed Scopus (317) Google Scholar Although RV failure after LVAD implantation is known to portend worse clinical outcomes, the degree to which this relates to duration of inotropic support post-implantation is unknown. Furthermore, this stratification approach may be confounded by heterogeneity in inotrope weaning protocols among different institutions. With this in mind, we sought to evaluate clinical outcomes associated with the INTERMACS RHF stratification system. Interagency Registry for Mechanically Assisted Circulatory Support. Appendix A - adverse event definitions. UAB School of Medicine. http://www.uab.edu/medicine/intermacs/appendices/app-a-5-0. Accessed February 13, 2017. Interagency Registry for Mechanically Assisted Circulatory Support. Appendix A - adverse event definitions. UAB School of Medicine. http://www.uab.edu/medicine/intermacs/appendices/app-a-5-0. Accessed February 13, 2017.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
