Abstract

Objective:To evaluate the safety and clinical efficacy of high-intensity focused ultrasound (HIFU) in the treatment of malignant liver cancer. Methods:HIFU treatment was performed in 58 patients with malignant liver cancer proved by biopsy. Of all the patients 35 cases had primary liver cancer and 23 cases had metastatic liver cancer. The clinical efficacy of HIFU was observed by comparison of clinical symptoms, laboratory testing results, imaging examination, and survival follow-up data before and after treatment. Results:At one month after treatment, CT and MRI examinations showed that the tumor had complete coagulative necrosis in 14 patients (24.1%), 75% necrosis in 35 patients (60.3%), and 50% necrosis in 9 patients (15.5%). The number of AFP-positive PLC patients decreased by 78.9% (15/19). The total 1-year survival rate was 43%. It was 54% for PLC patients and 26% for MLC patients. Conclusion:HIFU is effective and feasible in the treatment of liver cancer. It offers a non-invasive therapy for local treatment of liver cancer.

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