Abstract
The objective of present study is to recognizing risk factors those are associated with poor outcome in children with severe malaria. A Prospective observational study was set in Pediatric Intensive Care Unit of tertiary care hospital. A 170 cases of severe malaria between the age group of 6 months to 12 years of either sex with confirmed slide positivity for malaria parasite who satisfied WHO 2000 criteria for severe malaria were enrolled, after approval from institutional ethical committee and parent's informed consent. Detail clinical evaluation was done including assessment of various risk factors like respiratory distress syndrome, multiorgan dysfunction, hypoglycemia, jaundice, renal failure, impaired conscious, cerebral malaria, spontaneous bleeding, hyperparasitemia, shock and severe anaemia. Case fatality ratio was 19.4% and maximum in the age group between 6 months to 2 years. A MODS was most significant variable associated with poor outcome followed by shock, coma and bleeding tendency. MODS, shock, cerebral malaria and bleeding tendency are significant variable predicting poor outcome with severe malaria.
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