Abstract
Clinical Management of Uveitis in Systemic Rheumatic Autoimmune Diseases in Adults
Highlights
The eye has a particular relationship with the immune system which is known as “immune privilege” and involves physical barriers, immunosuppressive factors and protein antigens [1]
In other systemic autoimmune rheumatic diseases (SARD), including some cited in this review, these features are relatively unknown, as it happens with the link between ocular inflammation and manifestations in other organs
It is probable that each step taken towards a better clinical management of autoimmune uveitis (AIU) in each disease will enhance the knowledge of AIU associated with other SARD, but it must not be forgotten that each one has its particularities
Summary
The eye has a particular relationship with the immune system which is known as “immune privilege” and involves physical barriers, immunosuppressive factors and protein antigens [1]. Uveitis can be a co-manifestation of systemic autoimmune rheumatic diseases (SARD), a side effect of medications, a consequence of exposure to toxins or just an idiopathic disorder [5]. It has been traditionally categorized as infectious or non-infectious [6]. Non-infectious uveitis is believed to be either autoimmune, when it is mediated by aberrant immune recognition of self, or immune-mediated, if an innate inflammatory reaction is triggered by environmental or autologous signals [8,9]. AIU is considered to include both organ-specific and SARD-associated uveitis, regardless of which immune response (adaptive or innate) predominates
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