Clinical features of patients with PEVAC in University Hospital of Canarias

Abstract

AbstractPurposeTo investigate the clinical characteristics of Perifoveal Exudative Vascular Anomalous Complex (PEVAC) patients diagnosed in the University Hospital of Canarias.MethodsThis retrospective study included 7 eyes (of 7 patients) diagnosed with PEVAC. We reviewed the demographic characteristics. All of our patients had undergone a complete ophtalmological examination including color retinography, autofluorescence, Optical Coherence Tomography (OCT), fluorescein angiography(FA) and OCT‐Angiography (OCTA). We also reviewed the follow‐up information.ResultsOf our 7 patients, 3 were women and 4 were men. The average age and standard deviation were 71.0 +‐12.8 years. Average visual acuity was 0.54 + −0.24.Of our 7 patients, 4 had no remarkable comorbidities, 2 had age‐related macular degeneration and the resting patient had myopic degeneration. PEVAC presented as a big isolated perifoveal aneurysm. On OCT PEVAC appeared as a round hyperreflective lesion, typically surrounded by intraretinal cystic spaces. FA showed a well defined hyperfluorescent lesion with variable leakage. OCTA revealed that the isolated aneurysmatic lesion was located in the superficial capillary plexus in 2 cases; in the deep capillary plexus in 4 cases and in one cases it seemed to be in the intermediate plexus. In 5 cases, there was only subtle exudation that did not require treatment, remaining stable during follow‐up. In two cases, exudation was greater, so we treated them with anti‐VEGF, with partial response.ConclusionsPEVAC is an aneurysmatic isolated perifoveal abnormality that can occur in patients with or without retinal disease. PEVAC did not respond to anti‐VEGF therapy.Bibliography Querques G, Kuhn D, Massamba N, Leveziel N, Querques L, Souied EH. Perifoveal Exudative Vascular Anomalous Complex. J Fr Ophtalmol 2011; 34(8): 559.e1–4. Sacconi R, Freund KB, Yannuzzi LA, Dolz‐Marco R, Souied E, Capuano V, et al. The Expanded Spectrum of Perifoveal Exudative Vascular Anomalous Complex. Am J Ophthalmol 2017; 184:137–146. Mrejen S,Le HM,Nghiem‐Buffet S,Tabary S,Quentel G,Cohen SY. Insights into Perifoveal Exudative Vascular Anomalous Complex. Retina 2020;40(1):80–86.