Abstract
Objective To investigate the curative effect and toxicity of consolidation chemotherapy following concurrent chemoradiotherapy after radical surgery on patients with high-risk early stage cervical squamous cancer. Methods A total of 135 high-risk patients with clinical FIGO 2009 stage ⅠB1-ⅡA who had undergone radical surgery were divided into consolidation group(68 cases)and observation group(67 cases). The patients in the observation group were treated with DDP concurrent chemoradiotherapy alone, while in the consolidation group, DTX 75 mg/m2(d1), and DDP 75 mg/m2(d1-3) were given every three weeks for 3 cycles. The endpoint was OS, toxic and side effect. Results The 3-year overall survival rate were 88.0% and 71.4%, respectively, (P=0.03); there was no significant difference in the incidence of grade 3 or 4 reactions between the two groups(P>0.05). Conclusions The consolidation chemotherapy after CCRT following radical surgery may improve overall survival, and it is well tolerated for patients with high-risk early stage cervical cancer. Key words: High-risk early stage squamous cell cervical squamous carcinoma; Consolidation chemotherapy; Concurrent chemoradiotherapy; Curative effect; Toxic and side effects
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