Abstract
This study aimed to investigate clinical efficacy of cefoperazone-sulbactam in patients with acute myocardial infarction complicated by infection and effects on serum procalcitonin and serum inflammatory indicators. Prospective analysis was used in this study. A total of 109 cases of patients with acute myocardial infarction complicated with infection were collected. They were admitted to our hospital from August 2018 to September 2019 and were divided into a control group and an experimental group according to different treatment methods. Patients (53 cases) in the control group received treatment of cefoperazone, while patients (56 cases) in the experimental group received treatment of cefoperazone-sulbactam. Therapeutic effect, bacterial clearance rate and adverse reaction of the two groups were compared. Serum procalcitonin (PCT) and serum hypersensitive C-reactive protein (hs-CRP) levels were observed and compared. ROC curve was used to analyze the predictive value of PCT, hs-CRP for the treatment of acute myocardial infarction complicated by infection. Logistic regression analysis was used to analyze the risk factors for the effect of acute myocardial infarction complicated by infection. The effective rates and bacterial clearance rates of treatment in the experimental group were higher than those in the control group (P<0.05). After treatment, the PCT and hs-CRP levels of the experimental group were lower than those of the control group (P<0.05). Age, hypertension, length of hospital stay, heart failure and hs-CRP were independent risk factors affecting the effective rate of treatment for acute myocardial infarction complicated by infection. In conclusion, cefoperazone-sulbactam has good therapeutic effect on acute myocardial infarction complicated with infection. It can reduce the level of PCT and serum inflammatory indicator hs-CRP; PCT and hs-CRP have certain predictive value on the therapeutic effect, which is worthy of promotion.
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