Abstract
We investigated the clinical manifestations and course of all probable severe acute respiratory syndrome (SARS) patients in the Vietnam outbreak. Probable SARS cases were defined by using the revised World Health Organization criteria. We systematically reviewed medical records and undertook descriptive statistical analyses. All 62 patients were hospitalized. On admission, the most prominent symptoms were malaise (82.3%) and fever (79.0%). Cough, chest pain, and shortness of breath were present in approximately one quarter of the patients; 79.0% had lymphopenia; 40.3% had thrombocytopenia; 19.4% had leukopenia; and 75.8% showed changes on chest radiograph. Fever developed on the first day of illness onset, and both respiratory symptoms and radiographic changes occurred on day 4. On average, maximal radiographic changes were observed on day 10, and fevers subsided by day 13. Symptoms on admission were nonspecific, although fever, malaise, and lymphopenia were common. The complications of SARS included invasive intubation and ventilation (11.3%) and death (9.7%).
Highlights
We investigated the clinical manifestations and course of all probable severe acute respiratory syndrome (SARS) patients in the Vietnam outbreak
The first SARS case-patient in Vietnam was admitted to the hospital on February 26, 2003, and the last case-patient was admitted on April 8, 2003
All 62 patients with probable SARS were admitted to hospitals in Hanoi, Vietnam
Summary
We investigated the clinical manifestations and course of all probable severe acute respiratory syndrome (SARS) patients in the Vietnam outbreak. The most prominent symptoms were malaise (82.3%) and fever (79.0%). Fever developed on the first day of illness onset, and both respiratory symptoms and radiographic changes occurred on day 4. Symptoms on admission were nonspecific, fever, malaise, and lymphopenia were common. SARS spread to other countries and regions, such as the Hong Kong Special Administrative Region of China, Vietnam, Singapore, Canada, and Taiwan. Two independent teams [4,5] confirmed the novel coronavirus was associated with SARS infections in patients from Hong Kong, Vietnam, Canada, and Taiwan. This article describes the clinical and laboratory features of patients with SARS in Hanoi, Vietnam
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