Clinical correlation of intra-ductal lesion and breast nipple discharge in Xinjiang area: a study based on 3154 cases

Abstract

Objective To explore the relationship between intra-ductal lesion and breast nipple discharge in Han,Uyghur and Kazakh ethnic patients in Xinjiang Uygur Autonomous Region.Methods Fiberoptic ductoscopy and surgery were performed in 3154 pathologically confirmed intra-ductal lesion patients and clinical data were retrospectively analyzed.Results Of 3154 patients with intraductal lesions,335 were usual ductal hyperplasia (UDH,10.62％),312 were atypical ductal hyperplasia (ADH,9.87％),57 were ductal carcinoma in situ (DCIS,1.81％),2223 were intraductal papilloma (IDP,77.91％),and 227 were infiltrating ductal carcinoma (IDC,7.20％).In 71.99％ of reported cases,ages ranged from 30 to 50 years with no statistical significance between different ethnic groups (P ＞ 0.05).ADH was mostly seen in Han patients (11.42％),UDH in Uygur patients (19.73％),and IDC in Kazakh patients (15.74％) (P ＜ 0.05).However,there was no significant differences shown for IDP and DCIS between different ethnic groups (P ＞ 0.05).The serous discharge was mainly seen in UDH (64.78％,217/335),ADH (59.94％,187/312),DCIS (45.61％,26/57),and IDP (46.92％,1043/2223).However,bloody discharge was mainly seen in IDC (84.14％,191/227),and DCIS (42.11％,24/57)with statistically significant differences (P ＜ 0.05).Conclusions Breast nipple discharge could be an early manifestation of intra-ductal lesions,and spectrum of intra-ductal lesions differs in different ethnic groups. Key words: Breast diseases ; Endoscopy ; Nipple discharge ; Intraductal lesion