Abstract
To investigate the clinical feature, risk factors and outcome of treatment in patients with liver failure complicated by invasive fungal infections. Retro-spective analysis of the clinical data and related factors of 27 patients with liver failure com-plicated by invasive fungal infections was per-formed. These patients were admitted from January 2007 to August 2009 in our department. Among them, Candida albicans accounted for 17cases (54.84%), albicans tropicals for 4 cases (12.90%). Fungal infection in respiratory tract and alimentary tract accounted for 58.06% and 11% respectively. 81.25% of them had fever fluctuating from 37.4oC to 40oC. 81.25% had elevated white blood cell counts .All had the usage of broad-spectrum of antibiotics, whereas some of them used corticosteroids and had invasive medical manipulation for the treatment. Most patients deteriorated after invasive fungal infections. 21 cases accepted with the treatment of antifungal drugs and mortality rate was 63.00%. It was found that the invasive fungal infection possibility of patients with liver failure significantly increased. To prevent the occurrence of invasive fungal infection, promptly early treatment of liver failure, proper use of antibiotics, cautious use or disuse of corticosteroids, reduction of invasive medical manipulation should be well done. Early detection and treatment of fungal infection are vital to decrease in mortality rate.
Highlights
With the widespread use of broad-spectrum of antibiotics and invasive medical manipulation for the treatment in clinical, the incidence of invasive fungal infections enhanced and candida albicans and aspergllus were the main infection strains [1]
Patients with liver failure can merge invasive fungal infections which would lead to high mortality rate
The clinical data and related factors of 27 patients are retrospectively analyzed, who are treated in our department because of liver failure complicated by invasive fungal infection
Summary
With the widespread use of broad-spectrum of antibiotics and invasive medical manipulation for the treatment in clinical, the incidence of invasive fungal infections enhanced and candida albicans and aspergllus were the main infection strains [1]. The patients with liver failure are prone to micro-ecological unbalance. Patients with liver failure can merge invasive fungal infections which would lead to high mortality rate. The clinical data and related factors of 27 patients are retrospectively analyzed, who are treated in our department because of liver failure complicated by invasive fungal infection
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