Abstract
The risk factors for predicting bone metastases in patients with breast cancer are still controversial. Here, a total of 2133 patients with breast cancer, including 327 with bone metastases (15.33%) and 1806 without bone metastases (84.67%) were retrospective reviewed from January 2005 to December 2015. The spine was found to be the most common site for bone metastases, followed by ribs (57.5%), pelvis (54.1%) and sternum (44.3%). The results indicated that axillary lymph node metastases and the concentrations of CA125, CA153, ALP and hemoglobin were the independent risk factors for bone metastases in patients with breast cancer. The receiver operating characteristics (ROC) curves showed that combined axillary lymph node metastases, high CA153 and ALP, with low hemoglobin were the most accurate biomarkers for predicting bone metastases in breast cancer [area under the curve = 0.900], and the sensitivity and specificity for the prediction were 78.5% and 87.8%, respectively. Therefore, breast cancer patients with more axillary lymph node metastases, high serum concentrations of CA125, CA153, ALP and low level of hemoglobin were closely related to bone metastases. Combined axillary lymph node metastases, CA153, ALP with hemoglobin have the highest predictive accuracy for bone metastases in breast cancer.
Highlights
Breast cancer is the most common malignant cancer in women and is the leading cause of cancer death for women worldwide
We aimed to investigate the correlation between clinical-pathological parameters and bone metastases, and identify the risk factors for bone metastases in patients with breast cancer
A total of 2133 patients were recruited in this study, including 327 with bone metastases (15.33%) and 1806 without bone metastases (84.67%) at the primary diagnosis
Summary
Breast cancer is the most common malignant cancer in women and is the leading cause of cancer death for women worldwide. Osteolytic metastases can cause dramatic bone loss, which resulted in skeletal related events (SREs), such as pathological fractures, severe pain, bone instability, spinal cord compression and hypercalcemia. These will reduce the quality of patients’ life[3]. Improving knowledge about the clinical characteristics and identification of the risk factors for bone metastases in breast cancer patients is important for early diagnosing and treatment. In this retrospective study, we tried to evaluate the incidence and distribution of bone metastases in breast cancer. Characteristics Age (years) 59 Gender (n) Woman Man Menopausal status (n) Premenopausal Postmenopausal Histopathology (n) Invasive ductal carcinoma Other types Unknown Axillary lymph node metastases# (n) N0 N1–3 N4 and more
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