Abstract
Leukocyte morphological parameters, also known as cell population data (CPD), are measured by Coulter automated hematology analyzers with VCS technology. In recent years, clinical applications of CPD have been extensively investigated. The studies have demonstrated that diagnostic utility of neutrophil CPD in acute bacterial infection, particularly their roles in differentiating post-surgical bacterial infection versus systemic inflammatory response syndrome. Lymphocyte CPD show also specific changes in viral infection, providing a potential new hematological parameter for viral infection. The clinical application of these leukocyte morphologic parameters offers many advantages. These parameters are generated during automated differential analysis without additional specimen requirements. They are quantitative, more objective and more accurate than manual differential counts since over 8000 leukocytes are simultaneously evaluated. This socalled VCS technology is analogous to microscopic evaluation of a peripheral blood smear, but uses the most modern technology to refine the output for increased accuracy. These CPDs have potential usefulness in clinical environments.
Highlights
The information about the peripheral blood leukocytes provided by the majority of hematology analyzers is the total white blood cell count with differentials (WBC-D)
We have previously demonstrated that the lymphocyte cell population data (CPD) exhibit significant changes in response to hepatitis B virus (HBV) infection [15], which include increase in lymphocyte volume (LV: 94.2 ± 4.1 vs. 87.7 ± 2.9; reference range: 81.9-93.5), volume standard deviation (LV-standard deviations (SD): 20.1 ± 3.9 vs. 14.5 ± 1.3; range: 11.9-17.1) as well as decrease in lymphocyte conductivity (LC: 101.1 ± 8.1 vs. 107.6 ± 4.5; range: 98.6-116.6)
These parameters are generated during automated differential analysis without additional specimen requirements. They are quantitative, more objective and more accurate than manual differential counts since over 8000 leukocytes are simultaneously evaluated. They have shown a better diagnostic performance, in post-surgical bacterial infection, than conventional parameters, such as total WBC, the percent neutrophils, manual band neutrophil count, absolute neutrophil count and C-reactive protein (CRP), which are traditionally used as indicators for acute infection
Summary
The information about the peripheral blood leukocytes provided by the majority of hematology analyzers is the total white blood cell count with differentials (WBC-D). WBC-D, known as leukocyte numerical parameters, has been widely accepted and used by clinicians and is generally considered to yield clinically useful information in health and disease state. Changes in leukocyte numerical parameters, such as neutrophil count, tend to be extremely variable and nonspecific, in newborn infants, the elderly and myelosuppressed patients where response is less dramatic. The neutrophil count can be normal or decreased despite clinical evidence of an acute infection. The leukocyte morphological parameters, known as cell population data (CPD), have been described and their potential clinical applications have been extensively investigated
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