Abstract
In recent years, pulmonary artery blood flow acceleration time (AT) has been believed to be applicable in the examination of fetal lung development. This study aims to evaluate the clinical significance of pulmonary artery blood flow AT as a parameter in monitoring of fetal pulmonary artery pressure. A total of 31 fetuses in midor late-term pregnancy with tricuspid regurgitation were set as the study group (congenital heart disease with a tricuspid regurgitation pressure difference of more than 20 mm Hg was excluded). A total of 68 normal fetuses in midor late-term pregnancy were selected as the control group (strictly screened for tricuspid regurgitation, congenital heart disease and other congenital diseases before inclusion). The average ATs of both groups were calculated. Correlations of pulmonary artery systolic pressure (PASP) and AT, as well as the ratio of AT to right ventricular ejection time (ET) (AT/ET ratio) of both groups were investigated by 1-way analysis of variance (ANOVA). The average AT of the study group was significantly lower than that of the control group (p < 0.0001). In the study group, AT negatively correlated with PASP (r = -0.52; p < 0.01), AT/ET ratio negatively correlated with PASP (r = -0.52; p < 0.01) and both showed statistical significance. The results indicated that fetuses in the study group showed lower ATs and AT/ET ratios than the control group. Acceleration times and AT/ET ratios decreased as PASP increased. Thus, AT and AT/ET ratio can be used clinically as new parameters for the qualitative and - to some extent - quantitative evaluation of fetal pulmonary artery pressure.
Highlights
In recent years, Schenone et al have introduced the determination of pulmonary artery blood flow acceleration time (AT) into the research on the development of fetal pulmonary tissues for the first time.[1]
AT negatively correlated with pulmonary artery systolic pressure (PASP) (r = –0.52; p < 0.01), AT/ejection time (ET) ratio negatively correlated with PASP (r = –0.52; p < 0.01) and both showed statistical significance
The results indicated that fetuses in the study group showed lower ATs and AT/ET ratios than the control group
Summary
Schenone et al have introduced the determination of pulmonary artery blood flow acceleration time (AT) into the research on the development of fetal pulmonary tissues for the first time.[1] Acceleration time is believed to be applicable to the examination of fetal lung development. Kim et al have managed to examine neonatal respiratory distress syndrome.[2] Previous studies have reported an association of AT and AT/ejection time (ET) ratio with the Doppler flow curve of the fetal pulmonary artery.[3,4,5] Till no report has been published on the association between AT and pulmonary artery pressure. Pulmonary artery blood flow acceleration time (AT) has been believed to be applicable in the examination of fetal lung development
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
