Abstract
On the example of clinical observation of severe respiratory syncytial virus (RSV) infection, which occurred with the development of a specific pneumonia complicated by acute respiratory distress-syndrome and disseminated intravascular coagulation syndrome, which caused a lethal outcome in the non-term (33-34 weeks gestation) child of two months of life, the clinical and pathomorphological features of the disease are shown. Immunomorphologic study after death allowed to demonstrate the most important stages of respiratory syncytial viral infection pathogenesis and to specify reasons of long-term airway obstruction, caused by complicated respiratory syncytial viral infection. It was indicated, that bronchial obstruction may be caused by qualitative changes of epithelial lumen of different bronchi, such as direct cytophatic effect of respiratory virus or reactive changes of lumen in the form of basal squamous cell differentiation of epithelial lumen and poor regeneration of respiratory epithelium in the later stages of the disease.
Highlights
On the example of clinical observation of severe respiratory syncytial virus (RSV) infection, which occurred with the development of a specific pneumonia complicated by acute respiratory distress-syndrome and disseminated intravascular coagulation syndrome, which caused a lethal outcome in the non-term (33-34 weeks gestation) child of two months of life, the clinical and pathomorphological features of the disease are shown
Патоморфология респираторно-синцитиальной вирусной инфекции достаточно хорошо изучена и описана в литературе [5], однако многие вопросы патогенеза, в том числе причины и механизмы развития характерных морфологических проявлений заболевания остаются неизученными
Наличие сохраняющегося цитопатического действия вируса даже на 30-е сутки заболевания с поражением респираторного эпителия альвеол приводит к значительному нарушению функционирования аэрогематического барьера, что существенно сужает возможности протезирования витальных функций и делает актуальным вопрос разработки эффективного этиотропного лечения респираторно-вирусной синцитиальной инфекции
Summary
On the example of clinical observation of severe respiratory syncytial virus (RSV) infection, which occurred with the development of a specific pneumonia complicated by acute respiratory distress-syndrome and disseminated intravascular coagulation syndrome, which caused a lethal outcome in the non-term (33-34 weeks gestation) child of two months of life, the clinical and pathomorphological features of the disease are shown. Актуальность изучения респираторно-синцитиальной вирусной инфекции (РСВИ) обусловлена широкой распространенностью среди детского населения, частым формированием тяжелых форм заболевания, требующих использования реанимационного пособия и нередко приводящих к смерти детей раннего возраста. Ежегодно в мире регистрируют 33,8 млн случаев РСВИ среди детей первых 5 лет жизни, из которых 3,4 млн переносят заболевание в тяжелой степени тяжести и требуют интенсивной терапии и реанимационного пособия.
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