Abstract
The article provides a theoretical justification for the development of a complex iodine metabolic composition based on an iodinepolymer complex (iodinol) and succinic acid. The research on the effectiveness of the proposed composition for the correction of energymetabolic disorders in calves with severe iodine deficiency was carried out. The objects of research were calves with clinical signs of iodine deficiency and pronounced energy metabolic disorders. During the experiment, it was found that the test calves showed a marked improvement in the clinical condition. The thyroid status normalized, the total protein and glucose indicators approached the physiological norm, and the reserve alkalinity of the blood increased. The energetic metabolic effect was due to the combined action of iodinol and succinic acid. The obtained results indicate the opening prospect of an injection method for the use of an iodine polymer complex based on iodine-iodide with polyvinyl alcohol (iodinol) in combination with sodium succinate, not only as an effective approach to cupping and eliminating the iodine deficiency symptoms, but also as an active energy-metabolic drug with a potentially high anti-infective activity.
Highlights
One of the global and vital problems of mankind is iodine deficiency
If iodine deficiency is present in the body of animals, the biosynthesis of thyroid hormones is disrupted, which leads to a decrease in the intensity of redox processes, and as a result all types of metabolism: protein, fat, carbohydrate, macro- and microelement, as well as energy metabolism are disrupted
Theoretical and experimental substantiation of the development of a complex iodine metabolic composition based on an iodine polymer complex and succinic acid for correction of energy metabolic disorders in conditions of severe iodine deficiency
Summary
One of the global and vital problems of mankind is iodine deficiency. ‘SOS for humanity’ – that is the name given by the World Health Organization experts to the problem of iodine deficiency. A more rational approach to the prevention of diseases associated with iodine deficiency, including ensuring appropriate regulation of metabolic processes in the body, may be the use of organic forms of iodine or chelated compounds [12,13]. It is this circumstance that was taken into account when determining the author’s exploratory studies in the development of a complex iodine-metabolic composition suitable for parenteral administration
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
