Clinical, anatomopathological manifestations and laboratory findings of COVID-19 in adults: a narative review

Abstract

Introduction: SARS-CoV-2, the causative agent of the COVID-19 pandemics can cause anything from asymptomatic infections to several clinical manifestations. This study aims to present signs, symptoms, anatomopathological diagnosis, clinical diagnosis and laboratory findings in patients with COVID-19 in a narrative review. Methods: Narrative review of studies available in PubMed/Medline database about clinical manifestations in adult patients which were published in English, Portuguese and Spanish. Results: 547 articles were found, out of which 450 were excluded and 3 studies were added to the existing ones, totalizing 100 articles that composed the analyzed data. The main signs and symptoms were fever, dry cough, fatigue, dyspnea, pneumonia, headache, myalgia, vomiting, diarrhea, productive cough, acute myocardial injury, coagulopathy and olfactory and taste disorders. Conclusions: The findings suggest a great variety and complexity of Covid-19 clinical presentations indicating that, many differential diagnoses must be considered.