Abstract
Objective To investigate the significance of serum high-sensitivity C-reactive protein (hsCRP) and procalcitonin (PCT) content in pregnant women with premature rupture of membranes for intrauterine infection. Methods From June 2016 to November 2018, a total of 100 pregnant women with premature rupture of membranes admitted to Changshu City Hospital of Traditional Chinese Medicine (New District Hospital) were selected, and were divided into non-infection group (35 cases) and infection group (65 cases) according to the pathological diagnosis of placenta. Fasting serum hsCRP and PCT levels were detected in both groups. According to the count of white blood cells in placental tissues under the microscope, the 65 cases in infection group were divided into mild infection (31 cases), moderate infection (21 cases) and severe infection (13 cases), respectively. Fasting serum hsCRP and PCT levels in pregnant women with different degrees of infection were analyzed, respetively. Results Serum hsCRP level (t = 8.441, P = 0.022) and PCT level (t = 7.752, P = 0.013) in infection group were significantly higher than those in non-infection group, with significant differences. The more serious the infection degree of pregnant women in the infection group, the higher levels of serum hsCRP (F = 14.512, P = 0.015) and PCT (F = 16.778, P = 0.021). The values of serum hsCRP and PCT on the predictive value of intrauterine infection of the premature rupture of membranes showed that the sensitivity, specificity, positive predictive value and negative predictive value of hsCRP + PCT in the early rupture of intrauterine infection were higher than that of any single index, but without significant difference (χ2 = 1.998, P = 0.368; χ2 = 0.933, P = 0.627; χ2 = 0.842, P = 0.656; χ2 = 1.940, P = 0.379). The etiological analysis of premature rupture of membranes revealed that Chlamydia trachomatis, desmoochromogen and bacteria were the major infectious pathogens. Conclusions Serum hsCRP and PCT levels could be used to predict the intrauterine infection in pregnant women with premature rupture of membranesn with high sensitivity and specificity, and helpful to the diagnosis and treatment. Key words: Premature rupture of membranes; Hypersensitive C-reactive protein; Procalcitonin; Intrauterine infection
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