Abstract
BackgroundTo analyze the clinical characteristics and chemo-resistance related factors of patients with resistant and non-resistant endometriosis-associated ovarian cancer (ovarian clear cell carcinoma and endometrioid carcinoma) by reviewing the data of epithelial ovarian cancer patients who received initial treatment in our hospital over a 12-year period.ResultsAmong the 304 patients, 17.1% were seen with platinum-based drug resistance. The ROC curve of continuous variables was drawn according to resistance situation, then they were grouped by age (< 48 or ≥ 48 years), tumor size (< 7 cm or ≥ 7 cm) and Ca125 (< 90 and ≥ 90 U/ml). In univariate analysis, age ≥ 48 years, initial symptom of abdominal distension or weight loss, abnormal preoperative serum Ca125, Ca125 < 90 U/ml, advanced FIGO stage, absence of endometriosis, bilateral tumors, lack of lymphadenectomy, positive lymph nodes, unsatisfactory initial cytoreduction surgery and history of breast cancer were all related to drug resistance in ovarian cancer. In multivariate analysis, advanced stage, lack of lymphadenectomy, positive lymph nodes and history of breast cancer were independent risk factors related to platinum-based drug resistance (P < 0.05).ConclusionFor patients of endometriosis-related ovarian cancer, platinum-based drug resistance were associated with advanced FIGO stage, lack of lymphadenectomy, positive lymph nodes and history of breast cancer.
Highlights
IntroductionTo analyze the clinical characteristics and chemo-resistance related factors of patients with resistant and non-resistant endometriosis-associated ovarian cancer (ovarian clear cell carcinoma and endometrioid carcinoma) by reviewing the data of epithelial ovarian cancer patients who received initial treatment in our hospital over a 12-year period
To analyze the clinical characteristics and chemo-resistance related factors of patients with resistant and non-resistant endometriosis-associated ovarian cancer by reviewing the data of epithelial ovarian cancer patients who received initial treatment in our hospital over a 12-year period
Univariate analysis showed that compared with the non-resistant group, there were more patients with age ≥ 48 years in the chemo-resistant group (71.15% vs 54.76%, P = 0.0294), more with symptoms of abdominal distension (32.69% vs 17.46%, P = 0.0125) and emaciation (11.54% vs 1.59%, P = 0.0002), fewer with normal level of Cancer antigen 125 (Ca125) (3.85% vs 21.03%, P = 0.0034) but more
Summary
To analyze the clinical characteristics and chemo-resistance related factors of patients with resistant and non-resistant endometriosis-associated ovarian cancer (ovarian clear cell carcinoma and endometrioid carcinoma) by reviewing the data of epithelial ovarian cancer patients who received initial treatment in our hospital over a 12-year period. Many scholars regard endometriosis-associated ovarian cancer(EAOC) as a special pathological type of epithelial ovarian cancer(EOC), including ovarian clear cell carcinoma (OCCC) and endometrioid carcinoma. Studies have reported that the clinical features and prognosis of patients with EAOC were different from those with other EOCs. Compared with ovarian serous carcinoma, the onset age of OCCC was younger (55 vs 64 years; median age) [1]. A study comparing early ovarian cancer and advanced ovarian cancer (I/II vs III/IV) reported that 57–81% of OCCC were diagnosed in early stage (I/II) [2]. Ren et al Journal of Ovarian Research (2018) 11:40 Variable Category Number(%)
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