Abstract
We investigated theexpression ofclaudin 6 in non-small-cell lung carcinomas (NSCLC) by immunohistochemistry. Samples of164 patients with NSCLC were studied by immunohistochemistry. Claudin 6 was expressed in 42 % ofcases. Its expression was significantly more frequent in adeno- than in squamous cell carcinoma (p=0.002). There was no association between theTNM status and claudin 6 expression. Claudin 6 associated with apoor prognosis ofthepatients and with ashort recurrence-free interval (p=0.002, p<0.001). The association with survival had independent prognostic value (p=0.011). The results show that claudin 6 can be regarded as amarker ofpoor prognosis in lung cancer. This is different to some other cancers, such as breast and cervical carcinoma suggesting that claudin 6 probably induces other cellular pathways in neoplastic lung cells than in those tumors. In lung cancer, adenocarcinomas were most abundantly positive indicating ahigher linkage ofclaudin 6 to glandular differentiation.
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Schedule a callMore From: Polish journal of pathology : official journal of the Polish Society of Pathologists
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