Abstract
We examined both pharmacological and functional characteristics of the calcium channels which trigger transmitter secretion from giant nerve terminals of squid. These calcium channels are insensitive to organic calcium channel blockers such as dihydropyridines and ω-conotoxin GVIA, moderately sensitive to cadmium, activated by very small depolarizations and slowly inactivating. We conclude that the characteristics of these presynaptic channels do not correspond to the properties of T-, L-, or N-type calcium channels found in other cells.
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