Abstract
Cisplatin (CDDP) is one of the most valuable antineoplastic drugs available for the treatment of testicular, ovarian, lung, head and neck cancers. However, the drug has severe toxic side effects of which nephrotoxicity and gastrointestinal toxicity are the major dose limiting factors. CDDP causes hypocalcemia and hypomagnesemia. Hypocalcemia has been demonstrated to effect the parathyroid gland and the neurohypophysis secretions, which in turn control the stomach smooth muscle contractility and the kidney function. In rats it induces stomach bloating and ulceration. Injections (i.v) of calcium have been demonstrated to prevent stomach bloating, ulceration and preserve normal kidney function[19]. Present is an effort to study the effect of CDDP on adrenal gland as another endocrine gland.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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