Abstract
Derived from linear (parental) precursor mRNA, circRNA are recycled exons and introns whose ends are ligated. By titrating microRNAs and RNA binding proteins, circRNA interconnect networks of competing endogenous RNAs. Without altering chromosomal DNA, circRNA regulates skeletal muscle development and proliferation, lactation, ovulation, brain development, and responses to infections and metabolic stress. This review integrates emerging knowledge of circRNA activity coming from genome-wide characterizations in many clades of animals. circRNA research addresses one of the main pillars of the One Health vision – to improve the health and productivity of food animals and generate translational knowledge in animal species.
Highlights
As described in following sections, circularized RNA (circRNA) activity significantly expands the functional capacity of pre-mRNA, just as the protein coding capacity is amplified by alternative splicing
In 34 paired samples of only rRNA being depleted and a combination of rRNA depleted with RNAse R treatment, most of circRNAs (50–80% of highly expressed circRNAs, respectively) detected in the rRNA- dataset were validated in the rRNA−/RNAseR+ dataset as well (Zhang et al, 2020)
When exploring the parental sequences of the circRNA, regardless of the time point, they identified several abundant circular candidates derive from myosin gene family, similar to the observations made by Liang et al (2017) in postnatal muscle tissues
Summary
Derived from linear (parental) precursor mRNA, circRNA are recycled exons and introns whose ends are ligated. By titrating microRNAs and RNA binding proteins, circRNA interconnect networks of competing endogenous RNAs. Without altering chromosomal DNA, circRNA regulates skeletal muscle development and proliferation, lactation, ovulation, brain development, and responses to infections and metabolic stress. This review integrates emerging knowledge of circRNA activity coming from genome-wide characterizations in many clades of animals. CircRNA research addresses one of the main pillars of the One Health vision – to improve the health and productivity of food animals and generate translational knowledge in animal species
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