Abstract
The potential for cinnamic alcohol, an important fragrance and flavour ingredient, to induce hypersensitivity or elicit reactions in humans was evaluated by analysing patch-test data. Data from a total of 16,530 patch tests were collected from fragrance and formulator companies on various consumer products, fragrance blends containing cinnamic alcohol, and on the material itself. This study indicates that cinnamic alcohol as present in consumer products and fragrance blends has no detectable potential to induce hypersensitivity. However, cinnamic alcohol itself can induce concentration-related hypersensitivity. The lowest cinnamic alcohol concentration which has been tested and reported as inducing hypersensitivity is 4%. Data for levels below 4%, available from the present survey (≤0·4%) and from a European survey (≤3·2%), reveal no induced hypersensitivity. Cinnamic alcohol at the concentrations present in consumer products and in fragrance blends has a very low potential to elicit sensitization as evidenced by only four confirmed reactions elicited by cinnamic alcohol in 16,530 patch tests. The data presented in this survey contribute valuable information regarding the safety of the use of cinnamic alcohol in consumer products and fragrances.
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