Abstract
Background: Zinc Oxide (ZnO) nanoparticles are used for various industrial and domestic purposes and its release into the environment leads to the adverse effects among humans. This study aimed to evaluate the effect of rat exposure to ZnO nanoparticles on the histopathology of the liver and pancreas tissues, and serum oxidative stress parameters. Methods: Eighty female adult Wistar rats were divided into eight experimental, control and sham groups. They received ZnO nanoparticles at 4, 8, 25, 50, 100, or 200 mg/kg, or normal saline intraperitoneally for 30 days twice a week. Then, the blood samples of the rats were collected by heart puncture for biochemical analyses, and then sacrificed. Finally, the liver and pancreas tissues were harvested for histopathological examinations. Results: Significant amounts of nanoparticles were accumulated in the liver and pancreas of the rats, causing tissue and cellular damages. The ZnO nanoparticles reduced the levels of serum triglyceride, glucose, cholesterol, albumin, and increased the bilirubin and liver enzymes, such as ALT, AST, ALP, amylase and lipase at high doses. In addition, the evidence of histopathological lesions, hyperemia, inflammatory cell infiltration, and necrosis were noted in the liver and pancreas tissue slides upon microscopic examinations. Finally, the body and liver weights decreased in the rat groups receiving ZnO nanoparticle dose dependently. Conclusion: ZnO nanoparticles had toxic effects on the liver and pancreas, leading to destructive tissue and cellular changes in the rats.
Highlights
Z inc Oxide (ZnO) nanoparticles are used for industrial and cosmetic purposes [1]
Considering the above issues, the present study aimed to investigate the effect of nano Zinc Oxide (ZnO) on the oxidative stress status among adult female Wistar rats by measuring MDA as an index of lipid peroxidation; liver and pancreas enzymes, as a function of the liver and pancreas conditions, and atomic absorption of the liver and histopathological changes in the liver and pancreas tissue
Body and organ weights: The results of this study indicated that ZnO-NP treatments in 4 mg/kg dose group increased body weight compared to the control, while weight
Summary
Z inc Oxide (ZnO) nanoparticles are used for industrial and cosmetic purposes [1]. The study of nanomaterials toxicity on living cells and environment is a vital and needed research field. Nanoparticle products offer advantages to the users and economy; these products cause health threats to the researchers, workers, and consumers. The toxicity of nanoparticles on living cells within the background of environmental air pollution has attracted much attention. Nanotechnology benefits the users and economy, exposure of workers, consumers and researchers to the potentially dangerous materials can lead to harmful health effects [2]. Zinc Oxide (ZnO) nanoparticles are used for various industrial and domestic purposes and its release into the environment leads to the adverse effects among humans. This study aimed to evaluate the effect of rat exposure to ZnO nanoparticles on the histopathology of the liver and pancreas tissues, and serum oxidative stress parameters
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