Abstract
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by neurocognitive decline and abnormal neuronal and glial deposition of hyperphosphorylated-tau in a pattern distinct from other tauopathies. These changes are hypothesized to occur following repeated mild traumatic brain injury. We report a case of CTE-like neuropathological changes, and features of motor neuron disease in a patient without history of either head trauma or participation in activities associated with increased risk of concussive or sub-concussive blows.
Highlights
Chronic traumatic encephalopathy (CTE) is characterized by neurocognitive decline and abnormal neuronal and glial deposition of hyperphosphorylated-tau in a pattern distinct from other tauopathies [1]
We report the first case of CTE-like neuropathological changes, and features of motor neuron disease (MND) [3], in a patient without history of either head trauma or participation in activities associated with increased risk of concussive or sub-concussive blows
Non-traumatic causes of tau accumulation have been reported in cases of epilepsy, which has been shown to be associated with abnormal tau accumulation [8] and can recapitulate some of the pathological features of CTE [9]
Summary
Chronic traumatic encephalopathy (CTE) is characterized by neurocognitive decline and abnormal neuronal and glial deposition of hyperphosphorylated-tau in a pattern distinct from other tauopathies [1] These changes are hypothesized to occur following repeated mild traumatic brain injury [2]. We report the first case of CTE-like neuropathological changes, and features of motor neuron disease (MND) [3], in a patient without history of either head trauma or participation in activities associated with increased risk of concussive or sub-concussive blows. The clinical and neuropathological findings -- tau deposition consistent with the pattern seen in CTE, TDP-43+ MND, and an antemortem clinical diagnosis of ALS -- are similar to the newly described entity of chronic traumatic encephalomyelopathy [3,10,11]. A history of traumatic brain injury is lacking in this case
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Pathology and Clinical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
