Abstract
Chronic purple grape juice consumption induces age-dependent changes on cognitive function in elderly women
Highlights
The current world scenario is characterized by a rapid and considerable increase in the elderly population [1]. This is critical information since the aging process is characterized by the progressive decline of physiological function that contributes to cognitive retardation and may increase the incidence of neurodegenerative diseases [2,3]
We evaluated the effect of chronic grape juice consumption on cognitive performance, anthropometric and biochemical parameters
The >70 group showed a tendency towards increased Brain Derived Neurotrophic Factor (BDNF) levels (p=0.069) after the supplementation (Table 3)
Summary
The current world scenario is characterized by a rapid and considerable increase in the elderly population [1] This is critical information since the aging process is characterized by the progressive decline of physiological function that contributes to cognitive retardation and may increase the incidence of neurodegenerative diseases [2,3]. The HAT/HDAC imbalance appears to be pivotal in triggering the neurodegenerative cascade of events [6] In this sense, increased levels of HDAC activity was detected in the hippocampi from aged rats [7]. Lower levels of global histone H4 acetylation in hippocampi from aged rats [7] These findings could be related to the decreased levels and/ or expression of genes that exert pivotal role on memory and synaptic plasticity during the aging process, including the Brain Derived Neurotrophic Factor (BDNF) [13]. Lower levels of peripheral BDNF are associated to the cognitive deficits in elderly people [14]
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