Abstract
Materials and methods In the present study, rats were treated for 7 days with saline or morphine (10 mg/kg). After 24 h or 7 days wash out period, locomotion, oral stereotypy and state dependent memory in passive avoidance test of animals were measured in the presence or absence of CB1 receptor antagonist (AM251, 5 mg/kg). Meanwhile the mRNA expression of CB1 receptors in some areas of male rat brain (striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala) were measured in chronic morphine treated animals by real time RT-PCR to evaluate the mechanism underly behavioural responses.
Highlights
Repeated administration of μ opioid receptor agonists elicit a progressive enhancement of the behavioural responses
The phenomenon is known as behavioural sensitization
It has been shown that psychostimulants and opioids induce behavioural sensitization
Summary
Repeated administration of μ opioid receptor agonists elicit a progressive enhancement of the behavioural responses.
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