Abstract
SummaryThree sisters, aged 18, 16 and 11 years, were suffering from familial jaundice with elevated direct bilirubin. Two of them had a brown pigmentation of the liver cells and had slight, diffuse gastrointestinal symptoms. They meet the criteria for Dubin‐Johnson's syndrome. The third, suffering from a very mild form of familial jaundice, had very little pigment in the liver cells. This case is difficult to classify, being either a Dubin‐Johnson's syndrome, a Rotor's syndrome, or a condition intermediate between these two. Attempts to characterize the hepatic pigment with histochemical methods were made and seem to indicate that the pigment belongs to the lipofuscins.
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