Abstract
We report a case of chronic hepatosplenic aspergillosis following immune reconstitution complicating colic aspergillosis in an AIDS patient with multicentric Castleman disease. Symptoms mimicked the clinical presentation of chronic disseminated candidiasis and responded to corticosteroid. This emerging entity enlarges the spectrum of fungal immune reconstitution inflammatory syndrome in the HIV setting.
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We report a case of chronic hepatosplenic aspergillosis following immune reconstitution complicating colic aspergillosis in an AIDS patient with multicentric Castleman disease
We report the first case, to our knowledge, of what we propose to name “chronic disseminated aspergillosis” as an Immune reconstitution inflammatory syndrome (IRIS) fungal syndrome occurring during HIV infection
Summary
We report a case of chronic hepatosplenic aspergillosis following immune reconstitution complicating colic aspergillosis in an AIDS patient with multicentric Castleman disease. Symptoms mimicked the clinical presentation of chronic disseminated candidiasis and responded to corticosteroid. This emerging entity enlarges the spectrum of fungal immune reconstitution inflammatory syndrome in the HIV setting. Immune reconstitution inflammatory syndrome (IRIS) is defined as the clinical worsening or appearance of an infectious disease after reversal of immune deficiency. Among fungal IRIS, cryptococcosis has been best described in HIV-infected patients and solid organ transplant recipients, whereas reports of IRIS associated with other fungi remain anecdotal [1]. We report here a new HIVassociated fungal IRIS, which we propose to name “chronic disseminated aspergillosis” given its similarities with chronic disseminated candidiasis [2, 3]
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