Abstract
Those factors which predispose a conception to abortion are poorly understood. While investigating the cytogenetic aspects of this problem chromosome studies were completed on 91 human abortions. Consistent chromosome aberrations were found in 24 of 54 spontaneous abortions and in one of the 37 therapeutic abortions. The frequency of abnormal karyotypes was highest by far in pathologic ova. A comparison of the sex chromatin and the gonosomes of placental specimens revealed only an 84 per cent concurrence. This poor correlation was apparently the result of difficulty in interpreting the chromatin pattern of placental nuclei plus a 9 per cent incidence of an XO karyotype among the spontaneous abortions. It would appear that the results of studies of the primary sex ratio based on the sex chromatin test alone are misleading.
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