Abstract
Chromosome segregation was studied in mouse/human and mouse/mouse T-lymphocyte hybrids, and in mouse/human, mouse/rabbit and mouse/rat B-lymphocyte hybrids. Chromosome loss was not random, it was moderate in mouse/mouse and mouse/rat lymphocyte hybrids, but extensive in mouse/human and mouse/rabbit lymphocyte hybrids. Chromosomes carrying genes coding for T-cell differentiation markers were preferentially retained in interspecific as well as intraspecific T-cell hybrids. In mouse/rabbit B-lymphocyte hybrids, only two of 750 cells from five independent mass cultures contained any rabbit chromosomes.
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