Chromosome banding pattern in acute myeloid leukaemia.

Abstract

Using the Giemsa technique the chromosome banding pattern was determined in bone marrow cells of 10 untreated patients with a recent diagnosis of acute myeloid leukaemia. 5 patients had a completely normal banding pattern whereas 5 patients had cells with karyotypic abnormalities. The latter group included one case with a pseudodiploid karyotype which would not have been detected by previous techniques. In the total material the karyotype analyses of the abnormal metaphases indicated a non random involvement of chromosomes nos. 8, 21 and the X chromosome.