Abstract
Chromosome studies of Dalton's lymphoma, which was originally developed in the DBA/2 mouse and later adapted to a close inbred strain of the Swiss albino mouse, revealed only one rb-marker in all cells bearing a modal number (71). After several successive in vivo passages of the tumor, a new cell clone appeared with a different modal number (70) and two rb-markers. This new cell clone gradually outnumbered the stem cells and an apparent enhancement in tumorigenicity was noted. C-banding of the new cell clone revealed that one of the two telomeric heterochromatin-bearing chromosomes, originally present in the stem cells, had been involved in a Robertsonian fusion to form the additional marker chromosome. G-banded analysis indicated the noninvolvement of chromosome #15 in the fusion.
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