Abstract
Chromosomes of 17 C57BL/6J mice receiving 600 r totalbody x irradiation were analyzed and compared to chromosomes of 6 normal mice. Seven mice developed leukemia and 10 did not. Chromosomes of 4 leukemic mice were examined. Mouse #1 (generalized leukemia) had cells with a mode of 40, variation above the mode, and a large marker chromosome. Mouse #2 (localized thymic leukemia) had 2 hyperdiploid modes of 41 and 42 in thymic tissue, but normal chromosomes were in the spleen and marrow. Mouse #3 (generalized leukemia) had modes of 40 and 41 in the thymus, spleen, and marrow. Mouse #4 (localized thymic leukemia) had a modal number of 41 with variation about the mode. One of the 10 irradiated nonleukemic mice had some cells with a pseudodiploid karyotype containing a minute chromosome, and another had a questionable abnormality consisting of increased variation about the mode. The remaining 8 mice had normal chromosomes. Aneuploidy in irradiated nonleukemic mice may be due to preleukemia or to persistent x-ray induced aberrations. The possibility of persistent chromosomal alterations after x ray suggests irradiation leukemias are not ideal for evaluation of the significance of aneuploidy in mouse preleukemia or leukemia. (auth)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
