Abstract
The chromosomes in 20 secondary neoplasms in the CNS were studied in fixations taken directly from the tumours. Three quarters of the metastases had a triploid mode, and three quarters of these were in the hypotriploid zone. Near-diploid stemlines were next in frequency; a hypodiploid mode was most common, and 2 such tumours had as low stemline number as 34 and 36, respectively. Tetraploid stemlines were not seen, but 1 metastasis had a pentaploid mode. In ordinary chromosome groups the deviations particularly involved groups C, D and G. Markers, and often a very high number, were ou nd in all but one stemline. A statistical analysis of the chromosomal representation demonstrated a correlation between the extent of the decrease of the acrocentrics and the frequency of markers. A study of the relative size of four different marker types indicated that these were formed by non-random mechanisms. In comparison with findings in neoplastic effusions the brain metastases showed more extreme numerical and structural features, possibly a property of neoplastic elements with a capacity to metastasize to the CNS.
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