Abstract
Chromatography on calcium phosphate of fibrinogen from bracken poisoned animals, followed by re-chromatography of individual fractions, confirmed the presence of an aggregated form of the molecule in this condition due to molecular association. The usefulness of this chromatographic medium for demonstrating both the presence and disruption of aggregated molecules is emphasized. The contribution of aggregated molecules of fibrinogen to the increased viscosity of bracken plasma, together with their shape, is largely responsible for the streaking phenomenon in blood smears from cattle in the terminal stages of the condition. Seromucoid from these animals is eluted later in DEAE cellulose chromatograms, indicating that quantitative changes in seromucoid are accompanied by changes in the seromucoid type. The probability that the heterogeneity of seromucoid fractions is not caused by molecular association, as with fibrinogen, but to qualitative differences in the molecular structure is mentioned. The changes observed in fibrinogen and seromucoid are discussed in relation to the clotting defect in bracken poisoning.
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