Abstract
DNA in cell nuclei is associated with chromatin proteins. The major structural components of chromatin appear to be quaternary histone complexes called nucleosomes. The two DNA sections, those in the nucleosomes and those in the linker regions, are susceptible to nuclease action, but the latter are more sensitive. Subcellular systems like permeabilized bacteria, DNA membrane complexes, or crude concentrated protein extracts are useful systems for the analysis of DNA replication in microorganisms. Isolated nuclei have been employed to investigate several steps in eukaryotic DNA replication. This subcellular system may also help to better understand the assembly of chromatin during replication.
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