Abstract
Studies concerning the mechanism of DNA replication and repair have advanced our understanding of the stable transmission through multiple cell cycles of a faithful genetic material. Recent work has shed light on possible means to ensure the stable transmission of information beyond just DNA and the concept of epigenetic inheritance has emerged. Considering chromatin-based information, key candidates have arisen as epigenetic marks including DNA and histone modifications, histone variants, non-histone chromatin proteins, nuclear RNA as well as higher-order chromatin organization. Thus, understanding the dynamics and stability of these marks following disruptive events during replication and repair and throughout the cell cycle becomes of critical importance for the maintenance of any given chromatin state. We will present our most recent work on this topic, considering mostly histone variant dynamics during the cell-cycle and in response to DNA damage.
Highlights
Studies concerning the mechanism of DNA replication and repair have advanced our understanding of the stable transmission through multiple cell cycles of a faithful genetic material
Maison C, Romeo K, Bailly D, Dubarry M, Quivy JP, Almouzni G: The SUMO protease SENP7 is a critical component of pericentric heterochromatin to ensure local HP1 enrichment
Szenker E, Lacoste N, Almouzni G: A developmental requirement for HIRAdependant H3.3 deposition revealed at gastrulation in Xenopus
Summary
Studies concerning the mechanism of DNA replication and repair have advanced our understanding of the stable transmission through multiple cell cycles of a faithful genetic material.
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