Abstract
Purpose To investigate macular choroidal thickness (CT), topographical variation, and associations between subfoveal choroidal thickness (SFCT) and age, gender, spherical equivalent (SE), and axial length (AL) in Chinese healthy mild and moderate myopia children aged 8 to 11 years. Methods One hundred twenty eyes from 120 healthy children were studied. Children were divided into mild and moderate myopia groups. AL and CT were evaluated. CTs were measured at the fovea, and 1 mm, 2 mm, and 3 mm nasal, temporal, superior, and inferior to the fovea. Results SFCT was 252.80 ± 46.95 µm in the whole population. AL was shorter in the mild myopia group (24.18 ± 0.69 mm) than in the moderate myopia group (24.97 ± 0.68 mm, P < 0.001), and SFCT was thicker in the mild myopia group (262.00 ± 40.57 µm) than in the moderate myopia group (236.00 ± 55.08 µm, P=0.005). The topographical variation was similar in refraction groups. CTs nasal to the fovea thinned gradually and were all significantly thinner than SFCT. CTs in the other three directions gradually thickened and peaked at locations of 2 mm to the fovea. Then, CTs thinned at 3 mm to the fovea. The thickest choroid is located temporal to the fovea. There were significant negative correlations between AL and SFCT in the mild myopia group and the whole population. No other correlations were found. Conclusions The topographical variations of choroidal thickness were similar in mild and moderate myopia groups with the thickest locations temporal to the fovea. SFCT was relatively stable in children in narrow range of age and refractive error.
Highlights
To investigate macular choroidal thickness (CT), topographical variation, and associations between subfoveal choroidal thickness (SFCT) and age, gender, spherical equivalent (SE), and axial length (AL) in Chinese healthy mild and moderate myopia children aged 8 to 11 years
AL was shorter in the mild myopia group (24.18 ± 0.69 mm) than in the moderate myopia group (24.97 ± 0.68 mm, P < 0.001), and SFCT was thicker in the mild myopia group (262.00 ± 40.57 μm) than in the moderate myopia group (236.00 ± 55.08 μm, P 0.005). e topographical variation was similar in refraction groups
Most subjects in the studies were selected in a wide range of age and refractive error, even in the researches aimed at children. e choroidal thickness obtained in the studies might be general if the age range of the subjects was from 3 to 17 years [9], from 6 to 19 years [10], and the refractive error range was from −9.00 diopters (D) to +5.25 D [11], from −11.38 D to +8.38 D [10]. e correlations between choroidal thickness and other ocular biological parameters are significant in wide range of age and refractive error
Summary
Choroidal Thickness in Chinese Children Aged 8 to 11 Years with Mild and Moderate Myopia. E topographical variations of choroidal thickness were similar in mild and moderate myopia groups with the thickest locations temporal to the fovea. E correlations between choroidal thickness and other ocular biological parameters are significant in wide range of age and refractive error. In the study of high myopia, axial length was not related statistically to choroidal thickness in the control group when the refractive error was −0.3 ± 1.8 D (range, −6 D to +6 D) [6]. We aimed at investigating macular choroidal thickness in a narrow range of age and refractive error. Is study explored the characteristics of choroidal thickness in children with mild and moderate myopia of this age group. Axial length was measured using IOLMaster 500 (Carl Zeiss Meditec, Jena, Germany)
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