Abstract
Effective delivery of therapeutic molecules by proper surface-modified nanomaterial can disallow the progression of cancer. We report an effective treatment approach based on targeted delivery of ruthenium pro-drug (Ru) by poly ethylamine (PEI) coated ZnO–SiO2 core–shell nanoparticle for encapsulating large quantity of Ru pro-drug and subsequently grafted with functionalized with cholic acid (CA) as a tumor-specific moiety. An elaborate mechanism of core–shell formation and the size, composition, and morphology were characterized with diverse physiochemical studies such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FT-IR). Further, the anti-tumor activity of CA–Ru–PEI–ZnO–SiO2 nanoparticle was confirmed by in vitro studies. The synthesized CA–Ru–PEI–ZnO–SiO2 has a wide core with thicker outer shell showed excellent biocompatibility and a high potential for loading Ru pro-drug for anti-cancer therapy.
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